Papers

FULL PUBLICATION LIST

Quail DF, Olson OC, Bhardwaj P, Walsh LA, Akkari L, Quick M, Chen IC, Wendel N, Ben-Chetrit N, Walker J, Holt PR, Dannenberg AJ and Joyce JA (2017). Obesity alters the lung myeloid cell landscape to enhance breast cancer metastasis via IL5 and GM-CSF.  in press

Olson OC, Kim H, Quail DF, Foley EA and Joyce JA (2017). Tumor-associated macrophages suppress the cytotoxic activity of antimitotic agents. Cell Reports 19: 101-113  Link   PDF   

Quail D and Joyce JA (2017). The microenvironmental landscape of brain tumors. Cancer Cell 31: 326-341.   Link   

PDF   

Quail D and Joyce JA (2017). Multifaceted effects of the microenvironment on tumour progression. Nature Reviews Cancer   Link   PDF

Quail D and Joyce JA (2017). Molecular pathways: Deciphering mechanisms of resistance to macrophage-targeted therapies. Clinical Cancer Research 23: 876-884.   Link   PDF

Carmona-Fontaine C, Deforet M, Akkari L, Thompson CB, Joyce JA and Xavier JB (2017). Metabolic origins of spatial organization in the tumor microenvironment. PNAS 114: 2934-2939.   Link  

Quail DF, Bowman RL, Akkari L, Quick ML, Schuhmacher AJ, Huse JT, Holland EC, Sutton JC and Joyce JA (2016). The tumor microenvironment underlies acquired resistance to CSF-1R inhibition in gliomas. Science 352: aad3018.   Link   PDF

Bowman RL, Klemm F, Akkari L, Pyonteck SM, Sevenich L, Quail DF, Dhara S, Simpson K, Gardner EE, Iacobuzio-Donahue C, Brennan CW, Tabar V, Gutin PH and Joyce JA (2016). Macrophage ontogeny underlies differences in tumor-specific education in brain malignancies. Cell Reports 17: 2445-2459.   Link   PDF

Yan D, Wang H-W, Bowman RL and Joyce JA (2016). STAT3 and STAT6 signaling pathways synergize to promote cathepsin secretion from macrophages via IRE1a activation. Cell Reports 16: 2914-2927.   Link   PDF

Prudova A, Gocheva V, auf dem Keller U, Eckhard U, Olson OC, Akkari L, Butler G, Fortelny N, Lange PF, McLeod J, Joyce JA# and Overall CM# (2016). TAILS N-terminomics and proteomics shows protein degradation dominates over proteolytic processing by cathepsins in pancreatic tumors. (# Joint senior authors). Cell Reports 16: 1762-1773.   Link   PDF

Akkari L, Gocheva V, Quick M, Kester JC, Spencer AK, Garfall AL, Bowman RL and Joyce JA (2016). Combined deletion of cathepsin protease family members reveals compensatory mechanisms in cancer. Genes and Development 30: 220-232.   Link   PDF

Edgington-Mitchell LE, Gocheva V, van der Linden W, Verdoes M, Aurelio L, Graham B, Withana NP, Lieu TM, Parker BS, Joyce JA, Storz P, Bunnett NW and Bogyo M (2016). Macrophage-derived legumain is a biomarker for murine and human pancreatitis. American Journal of Physiology 311: G458-560.  Link

Akkari L and Joyce JA (2016). Microenvironmental InterFereNce of metabolism regulates chemosensitivity in cancer. Cell Research 26: 867-868.  Link   PDF

Curry RC, Faivre G, Akkari L, Joyce JA, Lin O, Rosenblum M, Diamond EL and Omuro A (2016). High dose methotrexate based chemotherapy as treatment for histolytic sarcoma of the central nervous system. Leukemia and Lymphoma 57: 1961-1964.  Link

Olson OC and Joyce JA (2015). Cysteine cathepsin proteases: regulators of cancer progression and therapeutic response. Nature Reviews Cancer 15: 712-729.  Link   PDF

Joyce JA and Fearon DF (2015). T cell exclusion, immune privilege and the tumor microenvironment. Science 348: 74-80.   Link   PDF

Klemm F and Joyce JA (2015). Microenvironmental regulation of therapeutic resistance in cancer. Trends in Cell Biology 25: 198-213.  Link   PDF

Sobotič B, Vizovišek M, Vidmar R, Van Damme P, Gocheva V, Joyce JA, Gevaert K, Turk V, Turk B and Fonović M (2015). Cysteine cathepsins modulate tumorigenesis through the shedding of cell adhesion proteins and receptors. Molecular Cellular Proteomics 14: 2213-2228.  Link   PDF

Hughes R, Qian BZ, Muthana M, Keklikoglou I, Olson OC, Tazzyman S, Danson S, Addison C, Gonzalez-Angulo AM, Joyce JA, De Palma M, Pollard JW and Lewis CE (2015). Perivascular M2 macrophage stimulate tumor relapse after chemotherapy. Cancer Research 75: 3479-3491.   Link   PDF

Brindle NR, Joyce JA, Rostker F, Lawlor ER, Swigart-Brown L, Evan G, Hanahan D, Shchors K. (2015). Deficiency for the cysteine protease cathepsin L impairs Myc-induced tumorigenesis in a mouse model of pancreatic neuroendocrine cancer. PLoS ONE 10:e0120348. doi:10.1371/journal.pone.0120348.   Link   PDF

Zhu W, Tao L, Quick ML, Joyce JA, Qu JM and Luo ZQ (2015). Sensing cytosolic RpsL by macrophages induces lysosomal cell death and termination of bacterial infection. PLoS Pathogens 11(3):e1004704.   Link   PDF

Sevenich L, Bowman R, Mason SD, Quail DF, Rapaport F, Elie BT, Brogi E Brastianos P, Hahn WC, Holsinger L, Massague J, Leslie CS and Joyce JA (2014). Analysis of tumour and stroma-supplied proteolytic networks reveals a brain metastasis-promoting role for cathepsin S. Nature Cell Biology 16: 876-888.   Link   PDF

Akkari L, Gocheva V, Kester JC, Hunter KE, Quick ML, Sevenich L, Wang HW, Peters C, Tang LH, Klimstra D, Reinheckel T and Joyce JA (2014). Distinct functions of macrophage- and cancer cell-derived cathepsin Z combine to promote tumor malignancy via interactions with the extracellular matrix. Genes and Development 28: 2134-2150.   Link   PDF

Sevenich L and Joyce JA (2014). Pericellular proteolysis in cancer. Genes and Development 28: 2331-2347.   Link   PDF

Bowman RL and Joyce JA (2014). Tumor-associated macrophages and microglia as therapeutic targets in glioblastoma. Immunotherapy 6: 663-666.   Link   PDF

Alonso-Curbelo D, Riveiro-Falkenbach E, Pérez-Guijarro E, Cifdaloz M, Osterloh L, Olmeda D, Megías D, Cañon E, Karras P, Calvo TG, Gómez-López G, Graña O, Checinska A, Wang HW, Pisano DG, Pastor J, Ortiz-Romero P, Torro D, Hoek K, Rodríguez-Peralto JL, Joyce JA and Soengas MS (2014). RAB7 controls melanoma progression by exploiting a lineage-specific wiring of the endolysosomal pathway. Cancer Cell 26: 61-76.   Link   PDF

Hunter KE, Palermo C, Kester JC, Simpson K, Li JP, Tang LH, Klimstra DS, Vlodavsky I and Joyce JA (2014). Heparanase promotes lymphangiogenesis and tumor invasion in pancreatic neuroendocrine tumors. Oncogene 33: 1799-1808.   Link   PDF

Dai P, Wang W, Cao H, Avogadri F, Dai L, Drexler I, Joyce JA, Merghoub T, Shuman S and Deng L (2014). Modified vaccinia virus Ankara triggers type I IFN production in conventional dendritic cells via a STING-mediated cytosolic DNA-sensing pathway. PLoS Pathogens 10(4):e1003989.   Link   PDF

Quail DF and Joyce JA (2013). Microenvironmental regulation of tumor progression and metastasis. Nature Medicine 19: 1423-1437.   Link   PDF

Pyonteck SM, Akkari L, Schuhmacher AJ, Bowman RL, Sevenich L, Quail D, Olson OC, Quick M, Huse J, Teijeiro V, Setty M, Leslie C, Oei Y, Pedraza A, Zhang J, Brennan CW, Sutton JC, Holland EC, Daniel D and Joyce JA (2013). CSF-1R inhibition alters macrophage polarization and blocks glioma progression. Nature Medicine 19: 1264-1272.   Link   PDF

Carmona-Fontaine C, Bucci V, Akkari L, Deforet M, Joyce JA and Xavier JB (2013). Emergence of spatial structure in the tumor microenvironment due to the Warburg effect. PNAS 110: 19402-19407.   Link   PDF

Krajcovic M, Krishna S, Akkari L, Joyce JA and Overholtzer M (2013). mTor regulates phagosome and entotic vacuole fission. Molecular Biology of the Cell 24: 3736-3745.   Link   PDF

Hunter KE, Quick ML, Sadanandam A, Hanahan D and Joyce JA (2013). Identification and characterization of poorly differentiated invasive carcinomas in a mouse model of pancreatic neuroendocrine tumorigenesis. PLoS ONE 8: e64472. doi:10.1371/journal.pone.0064472.   Link   PDF

Quail DF and Joyce JA (2013). Inflammation and cancer. The Molecular Basis of Cancer. Elsevier Publishing. Editors: Mendelsohn J, Gray JW, Howley PM, Israel MA, Thompson CB. Edition 4, Chapter 19, p285-295.   Link   PDF

Lujambio A, Akkari L, Simon J, Grace D, Zhao Z, Bolden JE, Joyce JA, Krizhanovsky V and Lowe SW (2013). Non cell-autonomous tumor suppression by p53 in liver cancer. Cell 153: 449-460.   Link   PDF

Olson OC and Joyce JA (2013). A splicing twist on metastasis. Science Translational Medicine 5:169fs2.   Link   PDF

Ryder M, Gild M, Hohl TM, Pamer E, Knauf J, Ghossein R, Joyce JA and Fagin JA (2013). Genetic and pharmacological targeting of CSF-1/ CSF-1R inhibits tumor-associated macrophages and impairs BRAF-induced thyroid cancer progression. PLoS ONE 8: e54302. doi:10.1371/journal.pone.0054302.   Link   PDF

Olson OC and Joyce JA (2013). Microenvironment-mediated resistance to anticancer therapies. Cell Research 23: 179-181.  Link   PDF

Jacobson LS, Lima H, Goldberg MF, Gocheva V, Tsiperson V, Sutterwala FS, Joyce JA, Gapp BV, Blomen VA, Chandran K, Brummelkamp TR, Diaz-Griffero F and Brojatsch J (2013). Cathepsin-mediated necrosis controls the adaptive immune response by Th2-associated adjuvants. Journal of Biological Chemistry 288: 7841-7891.   Link   PDF

Pyonteck SM, Gadea BB, Wang HW, Gocheva V, Hunter KE, Tang LH and Joyce JA (2012). Deficiency of the macrophage growth factor Csf-1 disrupts pancreatic neuroendocrine tumor development. Oncogene 31: 1459-1467.   Link   PDF

Shree T, Olson OC, Elie BT, Kester JC, Garfall AL, Simpson K, Bell-McGuinn KM, Zabor EC, Brogi E and Joyce JA (2011). Macrophages and cathepsin proteases blunt chemotherapeutic response in breast cancer. Genes and Development 25: 2465-2479.   Link   PDF

Mason SD and Joyce JA (2011). Proteolytic networks in cancer. Trends in Cell Biology 21: 228-237.   Link   PDF

Mason SD and Joyce JA (2011). Proteolytic cascades in invasion and metastasis. Cancer Metastasis: Biologic Basis and Therapeutics. Cambridge Univ. Press. Editors: Lyden DC, Welsh DR, Psaila B.   Link   PDF

Gocheva V, Wang HW, Gadea BB, Shree T, Hunter KE, Garfall A, Berman T and Joyce JA (2010). IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion. Genes and Development 24: 241-255.   Link   PDF

Wang HW and Joyce JA (2010). Alternative activation of tumor-associated macrophages by IL-4: priming for protumoral functions. Cell Cycle 9: 4824-4835.   Link   PDF

Gocheva V, Chen X, Peters C, Reinheckel T and Joyce JA (2010). Deletion of cathepsin H reduces angiogenic switching, tumor vascularization and growth in a mouse model of pancreatic cancer. Biological Chemistry 391: 937-945.   Link   PDF

Elie B, Gocheva V, Shree T, Dalrymple SA, Holsinger LJ and Joyce JA (2010). Identification and preclinical testing of a reversible cathepsin protease inhibitor reveals anti-tumor effects in a pancreatic cancer model. Biochimie 92: 1618-1624.   Link   PDF

Joyce JA and Pollard JW (2009). Microenvironmental regulation of metastasis. Nature Reviews Cancer 9: 239-252.   Link   PDF

Amankulor N, Hambardzumyan D, Pyonteck SM, Becher OJ, Joyce JA and Holland EC (2009). Sonic hedgehog pathway activation is induced by acute brain injury and regulated by injury-related inflammation. Journal of Neuroscience 29: 10299-10308.   Link   PDF

Chang SH, Kanasaki K, Gocheva V, Blum G, Harper J, Moses MA, Shih SC, Manseau EJ, Nagy JA, Joyce JA, Bogyo, M, Kalluri R and Dvorak HF (2009). Roles of cathepsins B/S/L and cysteine protease inhibitors in VEGF-A-induced angiogenesis. Cancer Research 69: 4537-4544.   Link   PDF

Palermo C and Joyce JA (2008). Cysteine cathepsin proteases as pharmacological targets in cancer. Trends in Pharmacological Sciences 29: 22-28.   Link   PDF

Abboud-Jarrous G, Atzmon R, Peretz T, Palermo C, Gadea B, Joyce JA and Vlodavsky I (2008). Cathepsin L is responsible for processing and activation of proheparanase through multiple cleavages of a linker segment. Journal of Biological Chemistry 283: 18167-18176.   Link   PDF

Gounaris E, Tung CH, Restaino C, Maehr R, Kohler R, Joyce JA, Ploegh H, Barrett T, Weissleder R and Khazaie K (2008). Live imaging of cysteine-cathepsin activity reveals dynamics of focal inflammation, angiogenesis, and polyp growth. PLoS One 3: e2916.   Link   PDF

Reinheckel T, Gocheva V, Peters C and Joyce JA (2008). Roles of cysteine proteases in tumor progression: analysis of cysteine cathepsin knockout mice in cancer models. The Cancer Degradome- Proteases and Cancer Biology. Springer Publishing.Eds. Edwards DR, Hoer-Hansen G, Blasi F, Sloane BF. p. 279-302.   Link   PDF

Bell-McGuinn K, Garfall A, Bogyo M, Hanahan D and Joyce JA (2007). Inhibition of cysteine cathepsin protease activity enhances chemotherapy regimens by decreasing tumor growth and invasiveness in a mouse model of multistage cancer. Cancer Research 67: 7378-7385.   Link   PDF

Gocheva V and Joyce JA (2007). Cysteine cathepsins and the cutting edge of cancer invasion. Cell Cycle 6: 60-64.   Link   PDF

Sadaghiani AM, Verhelst SHL, Gocheva V, Hill K, Majerova E, Stinson S, Joyce JA and Bogyo, M (2007). Design, synthesis and evaluation of in vivo potency and selectivity of epoxysuccinyl-based inhibitors of papain family cysteine proteases. Chemistry and Biology 14: 499-511.   Link   PDF

Gocheva V, Zeng W, Ke D, Klimstra D, Reinheckel T, Peters C, Hanahan D, and Joyce JA (2006). Distinct roles for cysteine cathepsin genes in multistage tumorigenesis. Genes and Development 20: 543-556.   Link   PDF

Gadea BB and Joyce JA (2006). Tumor-host interactions: implications for developing anticancer therapies. Expert Reviews in Molecular Medicine 8: 1-32.   Link   PDF

Joyce JA (2005). Therapeutic targeting of the tumor microenvironment. Cancer Cell 7: 513-520.   Link   PDF

Joyce JA, Freeman C, Meyer-Morse N, Parish C, and Hanahan D (2005).  A functional heparan sulfate mimetic implicates both heparanase and heparan sulfate in tumor angiogenesis and invasion in a mouse model of multistage cancer.  Oncogene 24: 4037-4051.   Link

Joyce JA, Hanahan D (2004). Multiple roles for cysteine cathepsins in cancer. Cell Cycle 3: 57-60.   Link

Joyce JA, Baruch A, Chehade K, Meyer-Morse N, Giraudo E, Tsai, F-Y, Greenbaum D, Hager JH, Bogyo M and Hanahan D (2004). Cathepsin cysteine proteases are effectors of angiogenesis and invasive growth during multistage tumorigenesis. Cancer Cell 5: 443-453.   Link

Joyce JA*, Laakkonen P*, Bernasconi M, Bergers G, Ruoslahti E and Hanahan D (2003). Stage-specific vascular markers revealed by phage display in a mouse model of pancreatic islet tumorigenesis. Cancer Cell 4: 393-403.   Link

Schofield PN, Joyce JA, Lam WK, Grandjean V, Ferguson-Smith A, Reik W and Maher ER (2001). Genomic imprinting and cancer; new paradigms in the genetics of neoplasia. Toxicology Letters 120: 151-160.   Link

Catchpoole DJ, Smallwood AV, Joyce JA, Murrell A, Lam WK, Tang TW, Munroe D, Reik W, Schofield PN, Maher ER (2000). Mutation analysis of H19 and NAP1L4 (hNAP2) candidate genes and IGF2 DMR2 in Beckwith-Wiedemann syndrome. Journal of Medical Genetics 37: 212-215.   Link

Smilinich NJ, Day CD, Fitzpatrick GV, Caldwell GM, Lossie AC, Cooper PR, Smallwood AC, Joyce JA, Schofield PN, Reik W, Nicholls RD, Weksberg R, Driscoll DJ, Maher ER, Shows TB, Higgins MJ (1999). A maternally methylated CpG island in KvLQT1 is associated with an antisense paternal transcript and loss of imprinting in Beckwith-Wiedemann syndrome. PNAS 96: 8064-8069.   Link

Lam WW, Hatada I, Ohishi S, Mukai T, Joyce JA, Cole TR, Donnai D, Reik W, Schofield PN, Maher ER (1999). Analysis of germline CDKN1C (p57KIP2) mutations in familial and sporadic Beckwith-Wiedemann syndrome (BWS) provides a novel genotype-phenotype correlation. Journal of Medical Genetics 36: 518-523.   Link

Joyce JA and Ferguson-Smith AC (1999). Genomic imprinting: its role in development and disease. Development: Genetics, Epigenetics and Environmental Regulation. (Eds. Russo VEA, Cove DJ, Edgar LG, Jaenisch R, Salamini F.)  p. 421-434.   Link

Joyce JA, Schofield PN (1998). Genomic imprinting and cancer. Molecular Pathology 51: 185-190.   Link

Catchpoole D, Lam WW, Valler D, Temple IK, Joyce JA, Reik W, Schofield PN, Maher ER (1997). Epigenetic modification and uniparental inheritance of H19 in Beckwith-Wiedemann syndrome. Journal of Medical Genetics 34: 353-359.   Link

Joyce JA, Lam WK, Catchpoole DJ, Jenks P, Reik W, Maher ER, Schofield PN (1997). Imprinting of IGF2 and H19: lack of reciprocity in sporadic Beckwith-Wiedemann syndrome. Human Molecular Genetics 6: 1543-1548.   Link

Brassett C, Joyce JA, Froggatt NJ, Williams G, Furniss D, Walsh S, Miller R, Evans DG, Maher ER(1996). Microsatellite instability in early onset and familial colorectal cancer. Journal of Medical Genetics 33: 981-985.   Link

Froggatt NJ*, Joyce JA*, Evans DG, Lunt PW, Koch DJ, Ponder BJ, Maher ER (1996). MSH2 sequence variations and inherited colorectal cancer susceptibility. European Journal of Cancer 32A: 178.   Link

Froggatt NJ, Joyce JA, Davies R, Gareth D, Evans R, Ponder BA, Barton DE, Maher ER (1995). A frequent MSH2 mutation in hereditary non-polyposis colon cancer syndrome. Lancet 345: 727.   Link

Joyce JA, Froggatt NJ, Davies R, Evans DG, Trembath R, Barton DE, Maher ER (1995). Molecular genetic analysis of exons 1 to 6 of the APC gene in non-polyposis familial colorectal cancer. Clinical Genetics 48: 299-303.   Link