Johanna Joyce Lab publications

Selected Publications

Click on selected links below or see all Joyce lab Publications on PubMed.

Quail DF, Olson OC, Bhardwaj P, Walsh LA, Akkari L, Quick ML, Chen IC, Wendel N, Ben-Chetrit N, Walker J, Holt PR, Dannenberg AJ and Joyce JA (2017). Obesity alters the lung myeloid cell landscape to enhance breast cancer metastasis through IL5 and GM-CSF. Nature Cell Biology 19:974-987

Yan D, Kowal J, Akkari L, Schuhmacher AJ, Huse JT, West BL and Joyce JA (2017). Inhibition of colony stimulating factor-1 receptor abrogates microenvironment-mediated therapeutic resistance in gliomas. Oncogene doi: 10.1038/onc.2017.261

Olson OC, Kim H, Quail DF, Foley EA and Joyce JA (2017). Tumor-Associated Macrophages Suppress the Cytotoxic Activity of Antimitotic Agents. Cell Reports 19:101-113

Quail DF and Joyce JA (2017). The microenvironmental landscape of brain tumors. Cancer Cell 31:326-341

Quail DF and Joyce JA (2017). Molecular pathways: dissecting mechanisms of resistance to macrophage-targeted therapies. Clinical Cancer Research 23: 876-884.

Bowman RL, Klemm F, Akkari L, Pyonteck SM, Sevenich L, Quail DF, Dhara S, Simpson K, Gardner EE, Iacobuzio-Donahue C, Brennan CW, Tabar V, Gutin PH and Joyce JA (2016). Macrophage ontogeny underlies differences in tumor-specific education in brain malignancies. Cell Reports 17: 2445-2459.

Yan D, Wang H, Bowman RL, Joyce JA (2016). STAT3 and STAT6 signaling pathways synergize to promote cathepsin secretion from macrophages via IRE1α activation. Cell Reports 16: 2914–2927.

Prudova A, Gocheva V, Auf dem Keller U, Eckhard U, Olson OC, Akkari L, Butler GS, Fortelny N, Lange PF, Mark JC, Joyce JA, Overall CM (2016). TAILS N-terminomics and proteomics show protein degradation dominates over proteolytic processing by cathepsins in pancreatic tumors. Cell Reports 16: 1762-1773.

Quail DF, Bowman RL, Akkari L, Quick ML, Schuhmacher AJ, Huse JT, Holland EC, Sutton JC, Joyce JA (2016). The tumor microenvironment underlies acquired resistance to CSF-1R inhibition in gliomas. Science 352: 6288

Akkari L, Joyce JA (2016). Microenvironmental InterFereNce of metabolism regulates chemosensitivity. Cell Research 26: 867-8.

Akkari L, Gocheva V, Quick ML, Kester JC, Spencer AK, Garfall AL, Bowman RL and Joyce JA (2016). Combined deletion of cathepsin protease family members reveals compensatory mechanisms in cancer. Genes and Development 30: 220-32.

Olson OC and Joyce JA (2015). Cysteine cathepsin proteases: regulators of cancer progression and therapeutic response. Nature Reviews Cancer 15: 712-29.

Joyce JA and Fearon DF (2015). T cell exclusion, immune privilege and the tumor microenvironment. Science 348: 74-80.

Klemm F and Joyce JA (2015). Microenvironmental regulation of therapeutic resistance in cancer. Trends in Cell Biology 25: 198-213.

Akkari L, Gocheva V, Kester JC, Hunter KE, Quick ML, Sevenich L, Wang HW, Peters C, Tang LH, Klimstra DS, Reinheckel T and Joyce JA (2014). Distinct functions of macrophage-derived and cancer cell-derived cathepsin Z combine to promote tumor malignancy via interactions with the extracellular matrix. Genes and Development 28: 2134-50.

Sevenich L and Joyce JA (2014). Pericellular proteolysis in cancer. Genes and Development 28: 2331-2347.

Sevenich L, Bowman R, Mason SD, Quail DF, Rapaport F, Elie BT, Brogi E, Brastianos P, Hahn WC, Holsinger L, Massague J, Leslie CS and Joyce JA (2014). Analysis of tumour and stroma-supplied proteolytic networks reveals a brain metastasis-promoting role for cathepsin S. Nature Cell Biology 16: 876-88.

Bowman RL and Joyce JA (2014). Tumor-associated macrophages and microglia as therapeutic targets in glioblastoma. Immunotherapy 6: 663-666.

Alonso-Curbelo D, Riveiro-Falkenback E, Perez-Guijarro E, Cifdaloz M, Osterloh L, Olmeda D, Megias D, Canon E, Karras P, Calvo TG, Gomez-Lopez G, Grana O, Checinska A, Wang HW, Pisano DG, Pastor J, Ortiz-Romero P, Torro D, Hoek K, Rodriguez-Peralto JL, Joyce JA and Soengas MS (2014). RAB7 controls melanoma progression by exploiting a lineage-specific wiring of the endolysosomal pathway. Cancer Cell 26: 61-76.

Hunter KE, Palermo C, Kester JC, Simpson K, Li JP, Tang LH, Klimstra DS, Vlodavsky I and Joyce JA (2014). Heparanase promotes lymphangiogenesis and tumor invasion in pancreatic neuroendocrine tumors. Oncogene 33: 1799-1808.

Pyonteck SM, Akkari L, Schuhmacher AJ, Bowman RL, Sevenich L, Quail D, Olson OC, Quick M, Huse J, Teijeiro V, Setty M, Leslie C, Oei Y, Pedraza A, Zhang J, Brennan CW, Sutton JC, Holland EC, Daniel D and Joyce JA (2013). CSF-1R inhibition alters macrophage polarization and blocks glioma progression. Nature Medicine 19: 1264-72.

Quail D and Joyce JA (2013). Microenvironmental regulation of tumor progression and metastasis. Nature Medicine 19: 1423-37.

Carmona-Fontaine C, Bucci V, Akkari L, Deforet M, Joyce JA and Xavier JB (2013). Emergence of spatial structure in the tumor microenvironment due to the Warburg effect. PNAS 110: 19402-19407.

Krajcovic M, Krishna S, Akkari L, Joyce JA and Overholtzer M (2013). mTor regulates phagosome and entotic vacuole fission. Mol Biol Cell 24: 3736-3745.

Hunter KE, Quick ML, Sadanandam A, Hanahan D, Joyce JA (2013). Identification and characterization of poorly differentiated invasive carcinomas in a mouse model of pancreatic neuroendocrine tumorigenesis. PLoS ONE. 8(5): e64472.

Lujambio A, Akkari L, Simon L, Grace D, Tschaharganeh DF, Bolden JE, Zhao Z, Thapar V, Joyce JA, Krizhanovsky V, Lowe SW (2013). Non-cell-autonomous tumor suppression by p53. Cell 153: 449-60.

Olson OC and Joyce JA (2013). A splicing twist on metastasis. Science Translational Medicine 5(169): 169fs2.

Ryder M, Gild M, Hohl TM, Pamer E, Knauf J, Ghossein R, Joyce JA, Fagin JA (2013). Genetic and pharmacological targeting of CSF-1/CSF-1R inhibits tumor-associated macrophages and impairs BRAF-induced thyroid cancer progression. PLoS ONE. 2013;8(1): e54302.

Olson OC and Joyce JA (2013). Microenvironment-mediated resistance to anticancer therapies. Cell Research 23: 179-81.

Pyonteck SM, Gadea BB, Wang HW, Gocheva V, Hunter KE, Tang LH and Joyce JA (2012). Deficiency of the macrophage growth factor Csf-1 disrupts pancreatic neuroendocrine tumor development. Oncogene 31: 1459-1467.

Shree T, Olson OC, Elie BT, Kester JC, Garfall AL, Simpson K, Bell-McGuinn KM, Zabor EC, Brogi E and Joyce JA (2011). Macrophages and cathepsin proteases blunt chemotherapeutic response in breast cancer. Genes and Development 25: 2465-2479.

Mason SD and Joyce JA (2011). Proteolytic networks in cancer. Trends in Cell Biology 21: 228-237.

Mason SD and Joyce JA (2011). Proteolytic cascades in invasion and metastasis. Cancer Metastasis: Biologic Basis and Therapeutics. Cambridge University Press. Editors: Lyden DC, Welsh DR, Psaila B.

Wang HW and Joyce JA (2010). Alternative activation of tumor-associated macrophages by IL-4: priming for protumoral functions. Cell Cycle 9: 4824-4835.

Gocheva V, Wang HW, Gadea BB, Shree T, Hunter KE, Garfall A, Berman T and Joyce JA (2010). IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion. Genes and Development 24: 241-255.

Gocheva V, Chen X, Peters C, Reinheckel T and Joyce JA (2010). Deletion of cathepsin H reduces angiogenic switching, tumor vascularization and growth in a mouse model of pancreatic cancer. Biological Chemistry 391: 937-945.

Elie B, Gocheva V, Shree T, Dalrymple SA, Holsinger LJ and Joyce JA (2010). Identification and preclinical testing of a reversible cathepsin protease inhibitor reveals anti-tumor effects in a pancreatic cancer model. Biochimie 92: 1618-1624.

Joyce JA and Pollard JW (2009). Microenvironmental regulation of metastasis. Nature Reviews Cancer 9: 239-252.

Chang SH, Kanasaki K, Gocheva V, Blum G, Harper J, Moses MA, Shih SC, Manseau EJ, Nagy JA, Joyce JA, Bogyo, M, Kalluri R and Dvorak HF (2009). VEGF-A induces angiogenesis by perturbing the cathepsin-cysteine protease inhibitor balance in venules, causing basement membrane degradation and mother vessel formation. Cancer Research 69: 4537-4544.

Amankulor N, Hambardzumyan D, Pyonteck SM, Becher OJ, Joyce JA and Holland EC (2009). Sonic hedgehog pathway activation is induced by acute brain injury and regulated by injury-related inflammation. Journal of Neuroscience 29: 10299-308.

Reinheckel T, Gocheva V, Peters C and Joyce JA (2008). Roles of cysteine proteases in tumor progression: analysis of cysteine cathepsin knockout mice in cancer models. The Cancer Degradome- Proteases and Cancer Biology. Springer Publishing. Eds. Edwards DR, Hoer-Hansen G, Blasi F, Sloane BF. p. 279-302.

Palermo C and Joyce JA (2008). Cysteine cathepsin proteases as pharmacological targets in cancer. Trends in Pharmacological Sciences 29: 22-28.

Abboud-Jarrous G, Atzmon R, Peretz T, Palermo C, Gadea BB, Joyce JA and Vlodavsky I (2008). Cathepsin L is responsible for processing and activation of proheparanase through multiple cleavages of a linker segment. Journal of Biological Chemistry 26: 18167-18176.

Gocheva V, Joyce JA (2007). Cysteine cathepsins and the cutting edge of cancer invasion. Cell Cycle 6: 60-64.

Sadaghiani AM, Verhelst SH, Gocheva V, Hill K, Majerova E, Stinson S, Joyce JA, Bogyo M (2007). Design, synthesis, and evaluation of in vivo potency and selectivity of epoxysuccinyl-based inhibitors of papain-family cysteine proteases. Chemistry and Biology 14: 499-511.

Bell-McGuinn K, Garfall A, Bogyo M, Hanahan D, and Joyce JA (2007). Inhibition of cysteine cathepsin protease activity enhances chemotherapy regimens by decreasing tumor growth and invasiveness in a mouse model of multistage cancer. Cancer Research 67: 7378-7385.

Gocheva V, Wei Z, Ke D, Klimstra D, Reinheckel T, Peters C, Hanahan D, Joyce JA (2006). Distinct roles for cysteine cathepsin genes in multistage tumorigenesis. Genes and Development 20: 543-556.

Gadea BB, Joyce JA (2006). Tumour-host interactions: Implications for developing anti-cancer therapies. Expert Rev Mol Med. 8: 1-32.

Joyce JA (2005). Therapeutic targeting of the tumor microenvironment. Cancer Cell 6: 513-520.

Joyce JA, Freeman C, Meyer-Morse N, Parish CR, Hanahan D (2005). A functional heparan sulfate mimetic implicates both heparanase and heparan sulfate in tumor angiogenesis and invasion in a mouse model of multistage cancer. Oncogene 25: 4037-4051.

Joyce JA, Baruch A, Chehade K, Meyer-Morse N, Giraudo E, Tsai, F-Y, Greenbaum D, Hager JH, Bogyo M, Hanahan D (2004). Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesis. Cancer Cell 5: 443-453.

Joyce JA, Hanahan D (2004). Multiple roles for cysteine cathepsins in cancer. Cell Cycle 12: 1516-1619.

Joyce JA, Laakkonen P, Bernasconi M, Bergers G, Ruoslahti E, Hanahan D (2003). Stage-specific vascular markers revealed by phage display in a mouse model of pancreatic islet tumorigenesis. Cancer Cell 5: 393-403.